1. Reflection of the scalp reveals no residual hematoma and no fracture of the skull. On the internal surface of the dura, there are fibrinous deposits, which are composed of gelatinous soft substance, in the left frontal parasagital area and the left occipital fossa, and scattered petechiae and diffuse brown discoloration in other areas.

2. Brain, which weighs 1,265 gram inclusively, externally shows marked softening of both the inferior aspect of the cerebral hemispheres, particularly extensive anemic necrosis (infarct) of the inferomedial aspect of the bilateral temporal and occipital lobes. Sections in the coronal plane reveal extensive infarct involving the inferomedial surface of the occipital lobes including optic radiation, bilateral Ammon's horn, hypothalamus, and the left globus pallidus and internal capsule( [jpg.43KB]). Meynert nuclei are also involved. Only minimal arteriosclerosis is noted in the basilar and vertebral arteries. Substantia nigra macroscopically remains pigmented but in decreased intensity ( [jpg.56KB]). Microscopic examination reveals anemic necrosis with mobilization of foam macrophages, lymphocytic infiltrates, capillary proliferation and reactive astrocytosis at the margins of the infarct, which also is involving the substantia nigra and the mid pons slightly. A few Lewy bodies are identified in the pigmented nuclei of the substantia nigra ( [jpg.66KB]) and the nucleus tractus solitarii but none in the locus coeruleus, nucleus dorsalis n. vagi, neither in the cerebral cortex. The number of pigmented neuronal cells is decreased in substantia nigra ( [jpg.80KB]) and locus coeruleus ( [jpg.98KB]) compared with an age- and sex-matched control (SN 847, 70-year-old male), accompanied with scattered pigment-laden macrophages. Lipofuscin deposition in the cytoplasm of the neuronal cells is remarkable in the cerebral cortex. Neuronal cells of the reticular formation including those in the nuclei ambiguus of the medulla oblongata are intact. Pallor of the bilateral pyramids is noticed in the pons and medulla oblongata, moderate, the left side being more prominent, and in the upper cervical spinal cord, mild.

3. The deceased is in the state after bar-hole operation for subdural hematoma that was performed at the neurosurgery clinic of this hospital in April 1998.

4. Microscopic infarct of the anterior pituitary gland (500 mg).

1. Focal pneumonia with consolidation of the right S-6 and moderate anthracosis of the lungs (540; 600 g), with the bilateral pleurae adherent to the chest wall and yellow clear effusion (300; 1,200 ml). Microscopic examination reveals formation of fibrous granulation tissue at the adhered right pleura that is composed of proliferation of fibroblasts and lymphocytic and granulocytic infiltrates. Focal organizing pneumonia is noted in the right S-6 and left S-9. Subpleural emphysema of mild degree is diffusely observed, in addition to subpleural scarring of both the apices.

2. Splenomegaly is noted with fairly firm consistency (270 g), without incisura. Microscopic examination reveals mild hemosiderin deposition.

3. The liver is mildly congestive, which weighs 1,550 gram. Microscopic examination reveals moderate fibrous enlargement of portal areas with dilated portal veins and lymphocytic infiltrates. Hepatocytes show deposition of lipofuscin pigments, otherwise are unremarkable

4. Mild congestion is noted in the kidneys (190; 170 g), with capsules stripped with ease with smooth surface. Microscopic examination reveals mild lymphocytic infiltrate in the interstitium, well-preserved glomeruli and mild arteriosclerosis of renal arteries.

5. Acute pancreatitis is noted microscopically, which consists of granulocytic infiltrate into the lumen of the pancreatic ducts, associated with interstitial fibrosis with granulocytic and lymphocytic infiltrates and atrophy of the acini.

6. Atrophy of endocrine organs; thyroid (9.5 g) and adrenals (6.5; 3.2 g), with lipoid depletion of the cortexes. No Lewy bodies are seen in the adrenal medulla.

7. Mixed bone marrow of the lumbar vertebrae, femur and sternum.

8. Healthy heart without scarring of the myocardium (360 g). Coronary arteries with remarkably scanty atheromas for a man of that age.

9. Elastic aorta with remarkably scanty atheromatous changes for a man of that age.

10. Testes show atrophy with tubular hyalinization with Sertoli cells only.

11. No Lewy bodies are seen in the Auerbach plexus of the sigmoid.

12. The deceased is an emaciated elderly man who weighs 38 kg and measures 160 cm in height with a scar of the left clavicular area that is consistent with a treated old fracture.